Publications by authors named "S E Strelkov"
Lens epithelium-derived growth factor p75 (LEDGF/p75), member of the hepatoma-derived growth-factor-related protein (HRP) family, is a transcriptional co-activator and involved in several pathologies including HIV infection and malignancies such as MLL-rearranged leukemia. LEDGF/p75 acts by tethering proteins to the chromatin through its integrase binding domain. This chromatin interaction occurs between the PWWP domain of LEDGF/p75 and nucleosomes carrying a di- or trimethylation mark on histone H3 Lys36 (H3K36me2/3).
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- The study investigates the role of a protein called CCDC158 in kidney function, specifically in the reabsorption of proteins in the renal proximal tubules, highlighting its importance in kidney and reproductive health.
- Whole exome sequencing identified a missense variant in CCDC158 in a male patient with kidney issues, which also appeared in a sister with similar symptoms, suggesting a hereditary component.
- Functional analyses showed that CCDC158 likely interacts with other proteins involved in endocytosis, affecting kidney function and contributing to conditions like proteinuria and oligospermia, but further research is needed to clarify its exact mechanisms.
Spatial variability in soil pH is a major contributor to within-field variations in soil fertility and crop productivity. An improved understanding of the spatial variability of soil pH within agricultural fields is required to determine liming requirements for precision farming. This study with the use of proximal sensors, firstly assessed the spatial pattern of soil pH and how it can be used to determine site-specific, spatially variable lime requirements.
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- Verticillium stripe disease has emerged as a significant threat to canola production in Canada, causing potential yield losses up to 50%.
- A study screened 211 plant genotypes, including rutabaga and canola, to assess their resistance to the pathogen and identified key SNP markers through genome-wide association studies (GWAS).
- Results showed that several non-commercial accessions demonstrated resistance, and 45 SNP markers were found associated with resistance, indicating potential for future canola breeding programs focused on disease resistance.