Soft tissue manipulation enhances recovery of muscle mass in a disuse model of sarcopenia.

Context: Sarcopenia is a disease characterized by low muscle mass and function that places individuals at greater risk of disability, loss of independence, and death. Current therapies include addressing underlying performance issues, resistance training, and/or nutritional strategies. However, these approaches have significant limitations, and chronic inflammation associated with sarcopenia may blunt the anabolic response to exercise and nutrition.

Inter-modality correlation across invasive and noninvasive angiography in the three-dimensional assessment of cerebral aneurysms.

Background: Non-invasive and invasive methods of cerebral angiography, including computed tomography angiography (CTA), magnetic resonance angiography (MRA), and digital subtraction angiography (DSA), are commonly used to characterize and follow cerebral aneurysms. Prior work has validated two-dimensional size measurements across these modalities. Our study aims to compare the reliability of three-dimensional (3D) shape measurements across CTA, MRA, and DSA.

Precision Stealth Nanofibers via PET-RAFT Polymerisation: Synthesis, Crystallization-driven Self-assembly and Cellular Uptake Studies.

Stealth precision polymer nanofibers show great promise as therapeutic delivery systems. However, existing systems are largely limited to poly(ethylene glycol) (PEG) and suffer from challenging functionalization, hampering their translation. This work develops a modular, easily functionalizable platform for biocompatible stealth nanofibers based on a combination of ring-opening polymerisation (ROP), photoinduced electron/energy transfer reversible addition-fragmentation chain transfer (PET-RAFT) polymerisation, and crystallization-driven self-assembly (CDSA).

Pharmacist Impact in a Post Neuro Intensive Care Virtual Clinic (PREVAIL).

Traditional Post-Intensive Care Recovery Clinics (PIRCs) often exclude neurocritical care patients. In 2020, a multidisciplinary team started Post Neuro Intensive Care Virtual Clinic (PREVAIL) that uses telemedicine to provide consultative care for patients with a primary neurologic injury who are at risk for post-intensive care syndrome. During clinic, critical care pharmacists perform medication reconciliations and provide drug therapy recommendations.

APOA2 increases cholesterol efflux capacity to plasma HDL by displacing the C-terminus of resident APOA1.

The ability of high-density lipoprotein (HDL) to promote cellular cholesterol efflux is a more robust predictor of cardiovascular disease protection than HDL-cholesterol levels in plasma. Previously, we found that lipidated HDL containing both apolipoprotein A-I (APOA1) and A-II (APOA2) promotes cholesterol efflux via the ATP-binding cassette transporter (ABCA1). In the current study, we directly added purified, lipid-free APOA2 to human plasma and found a dose-dependent increase in whole plasma cholesterol efflux capacity.