Publications by authors named "S E Sigurdsson"
The contribution of protons in or near biradical polarizing agents in Dynamic Nuclear Polarization (DNP) has recently been under scrutiny. Results from selective deuteration and simulations have previously suggested that the role of protons in the biradical molecule depends on the strength of the electron-electron coupling. Here we use the cross effect DNP mechanism to identify and acquire H solid-state NMR spectra of the protons that contribute to propagation of the hyperpolarization, via an experimental approach dubbed Nuclear-Nuclear Double Resonance (NUDOR).
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- Higher FSH levels are linked to bone loss during perimenopause and aging in men, but it was unclear if they independently increase fracture risk.
- A study analyzed 295 adults from the AGES-Reykjavik cohort to find out if baseline FSH levels could predict hip fractures within 10 years.
- Results showed that higher FSH levels significantly increased the risk of hip fractures, suggesting FSH might directly affect bone health beyond just being associated with sex hormones.
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- Patients with acute brain injuries like SAH and TBI can experience hidden deterioration that traditional monitoring might miss.
- A study involving 94 patients indicated significant links between elevated intracranial pressure, inadequate cerebral perfusion, hypoxia, and metabolic crises.
- Despite normal readings for intracranial pressure, brain hypoxia was found in 40% of SAH and 31% of TBI cases, showing the need for multimodal neuromonitoring to catch these issues and inform treatment.
Background: In intensive care patients with disorders of consciousness, the pupillary light reflex is a measure of pupillary parasympathetic function. By contrast, the pupillary light-off reflex leads to pupil dilation in response to an abrupt change from light to darkness ("light-off") and reflects combined parasympathetic and sympathetic pupillary function. To our knowledge, this reflex has not been systematically investigated in patients with disorders of consciousness.
View Article and Find Full Text PDFPhorbol ester analogs are a promising class of anticancer therapeutics and HIV latency reversing agents that interact with cellular membranes to recruit and activate protein kinase C (PKC) isoforms. However, it is unclear how these esters interact with membranes and how this might correlate with the biological activity of different phorbol ester analogs. Here, we have employed dynamic nuclear polarization (DNP) NMR to characterize phorbol esters in a native cellular context.
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