Publications by authors named "S E Schild"
Purpose: We report 5-year oncologic outcomes of a prospective series of patients with prostate cancer treated with spot-scanning proton therapy (SSPT).
Methods And Materials: A prospective registry identified patients with prostate cancer treated with SSPT between January 2016 and December 2018. Five-year overall survival, local control, biochemical failure, regional and distant failures, and adverse events (AEs) were assessed.
Article Synopsis
- Online adaptive proton therapy (oAPT) is crucial for managing anatomical changes in patients undergoing proton therapy for prostate cancer, and integrating AI-based autosegmentation can enhance its efficiency and accuracy.
- A new oAPT workflow was developed, integrating tools for spot arrangement and an LET-based evaluation to assess potential risks associated with high-dose treatments, which was validated on 11 prostate cancer patients.
- The results showed significant improvements in treatment planning quality, with high accuracy in dose delivery maintained, and the entire workflow took about 9 minutes on average to complete.
Article Synopsis
- - The study aimed to identify clinical and polysomnographic features of severe obstructive sleep apnea (OSA) in infants under 12 months, analyzing data from 207 infants referred for sleep-disordered breathing.
- - Results indicated that 43% of these infants had severe OSA, with age being the strongest predictor; particularly, infants three months or younger were at significantly higher risk and often exhibited additional complications like craniofacial abnormalities.
- - The most common management approach for these infants was observation with no interventions, while surgical options varied with age, including procedures like mandibular distraction osteogenesis for younger infants and adenoidectomy for those aged 4 to 12 months.
Article Synopsis
- Vibrio cholerae is a bacteria responsible for cholera that can transition between the human gut and aquatic environments, where it forms biofilms for survival.
- This study focuses on bacterial extracellular vesicles (BEVs) released by V. cholerae, discovering that BEVs from biofilm cultures enhance biofilm formation compared to those from free-floating (planktonic) cultures.
- A specific outer membrane protein, named ObfA, was identified as essential for this enhancement, acting as a negative regulator of the HapR protein, which normally suppresses biofilm formation and pathogenicity through a unique mechanism involving the Csr regulatory system.