[Effect of alpha- and gamma-tocopherols on the cytochrome P-450 system in the liver of rats with E-avitaminosis. Effectiveness of liposomal forms of gamma-tocopherol].

The effects of low doses of intraperitoneally injected alpha- and gamma-tocopherols dispersed in isotonic solutions of NaCl and of liposomal gamma-tocopherol on endogenous lipid peroxidation and the cytochrome P-450 system of vitamin E-deficient rats were compared. It was found that all tocopherol preparations under study caused a twofold decrease of the lipid Schiff base concentration in the liver in comparison with tocopherol-deficient rats. However, the increase in cytochrome P-450 and b5 levels and the high functional activity of the microsomal oxidation system in the benz(a)pyrene hydroxylation reaction was induced only after liposomal gamma-tocopherol injection.

[Anti-oxidant activity and tissue accumulation of tocopherols from a new source].

Properties of a tocopherol concentrate, obtained from side products of cotton oil treatment containing alpha-tocopherol and other isomers of vitamin E and carotinoids at high concentrations, were studied in vivo and in vitro. The concentrate exhibited higher antioxidative activity in reaction with 2,2'-diphenyl-1-picrylhydrazine and inhibited lipid peroxidation in liver microsomes similarly to synthetic alpha-tocopherol. After addition of the concentrate to rat ration at a dose of 100 IU of vitamin E per 100 g of food the animals accumulated tocopherol from this source in the same way as it was observed for the synthetic preparation (liver, heart, lung) or at the higher level (kidney, brain, fatty tissue).