Use of Intraoperative Frozen Section to Assess Surgical Margins in HPV-Related Oropharyngeal Carcinoma.

Importance: Given the favorable overall prognosis of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) and the morbidity of increased adjuvant therapy associated with positive surgical margins, large-scale studies on the accuracy of frozen sections in predicting final surgical margin status in HPV-related OPSCC are imperative. Final surgical margin status is the definitive assessment of tumor clearance as determined through surgeon-pathologist collaboration based on permanent analysis of frozen section margins, main specimens, and supplemental resections.

Objectives: To assess the accuracy and testing properties of intraoperative frozen section histology (IFSH) in assessing final surgical margin status in patients undergoing transoral surgery for HPV-related OPSCC.

Photo-Rechargeable Sodium-Ion Batteries with a Two-Dimensional MoSe Crystal Cathode.

Combining energy harvesting with energy storage systems in a single device could offer great advantages for continuous power supply in both indoor and outdoor electric applications. In this work, we demonstrate a photochargeable sodium-ion battery (PSIB) based on a photoactive cathode of two-dimensional crystals of MoSe. This photocathode enables spontaneous photodriven charging of a sodium-ion battery cathode under illumination and an increase in the reversible capacity to 29% at 600 mA g compared to that under dark conditions during galvanostatic cycling.

Antiproliferative Activity and Molecular Docking of Some Pyrazole-Based Quinazolinone, Benzimidazole, and Tetrazinethione Derivatives.

Researchers are actively looking for novel anticancer medications because cancer is one of the leading causes of mortality worldwide. A fascinating area of study in medicinal chemistry is the screening of antioxidants for novel anticancer medicines, as antioxidants have lately been used as therapeutic candidates to combat a variety of ailments in aerobic species. Additionally, pyrazole-based heterocycle synthesis is a productive approach to the drug development process.

Synthesis, in vivo evaluation, and in silico molecular docking of benzo[h]quinoline derivatives as potential Culex pipiens L. larvicides.

A new series of benzo[h]quinoline-containing heterocycles was synthesized via reactions of benzo[h]quinolinyl-2(3H)-furanone with some nitrogen bidentate nucleophiles, leading to the formation of pyridazinone, pyrrolinone, benzimidazole, and benzoxazinone derivatives. The synthesized compounds were evaluated for their insecticidal activity against Culex pipiens L. larvae.

Analysis of plasmon modes in BiSe/graphene heterostructures via electron energy loss spectroscopy.

Topological Insulators (TIs) are promising platforms for Quantum Technology due to their topologically protected surface states (TSS). Plasmonic excitations in TIs are especially interesting both as a method of characterisation for TI heterostructures, and as potential routes to couple optical and spin signals in low-loss devices. Since the electrical properties of the TI surface are critical, tuning TI surfaces is a vital step in developing TI structures that can be applied in real world plasmonic devices.