Publications by authors named "S E Olivan"
Article Synopsis
- Microfluidics technology is improving in vitro simulations of human tissues, particularly through organ-on-a-chip (OoC) devices that mimic the in vivo environment.
- A major challenge is the use of inert materials that prevent complete interaction between cells and nutrients, affecting cell responses negatively.
- The study focuses on designing two microfluidic devices to enhance cell-cell and cell-matrix interactions, featuring optimized pore sizes to reduce inert material interference and improve biological relevance.
Article Synopsis
- Nanotechnology, especially 2D materials like graphene-related materials (GRMs), has grown rapidly but raises safety concerns that need better assessment methods.
- Traditional testing methods aren't effective as they fail to replicate human physiological conditions, leading to issues like quick deposition and low stability of GRMs in solutions.
- The study introduces a kidney-on-a-chip microfluidic system that optimizes testing under realistic flow conditions to better evaluate the effects of graphene oxide and few-layer graphene exposure.
Organ-on-chip (OOC) technology has recently emerged as a powerful tool to mimic physiological or pathophysiological conditions through cell culture in microfluidic devices. One of its main goals is bypassing animal testing and encouraging more personalized medicine. The recent incorporation of hydrogels as 3D scaffolds into microfluidic devices has changed biomedical research since they provide a biomimetic extracellular matrix to recreate tissue architectures.
View Article and Find Full Text PDFGlioblastoma (GBM) is a highly malignant brain tumour characterised by limited treatment options and poor prognosis. The tumour microenvironment, particularly the central hypoxic region of the tumour, is known to play a pivotal role in GBM progression. Cells within this region adapt to hypoxia by stabilising transcription factor HIF1-α, which promotes cell proliferation, dedifferentiation and chemoresistance.
View Article and Find Full Text PDFOvarian tissue cryopreservation is gaining importance as a successful method to restore fertility to girls and young women at high risk of sterility. However, there are concerns regarding the safety of transplantation after ovarian tissue cryopreservation due to the high risk of reintroducing cancer cells and causing disease recurrence. In these cases, the development of culture systems that support oocyte development from the primordial follicle stage is required.
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