Publications by authors named "S E Nicol"
Background: Functional Capacity Evaluation (FCE) is a crucial component within return-to-work decision making. However, clinician-based physical FCE interpretation may introduce variability and biases. The rise of technological applications such as machine learning and artificial intelligence, could ensure consistent and precise results.
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- Oceanic eddies are crucial in marine ecosystems, attracting diverse marine life, including predators, by concentrating forage fauna.
- In a study of a thousand eddies, only 13% showed significant effects on forage fauna, with just 6% exhibiting a strong "oasis effect."
- Both anticyclonic and cyclonic eddies can create oases, but only high-amplitude eddies with strong water-mass-trapping significantly impact marine life, indicating complex interactions that require more research.
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- Pancreatic ductal adenocarcinoma (PDAC) is a tough cancer to treat because it can hide from the immune system, making it one of the deadliest types of cancer.
- Scientists want to learn more about why PDAC is so good at avoiding the immune system and how the gut microbiome, which helps our immune system, can impact this.
- Research shows that the gut microbiome can change the kinds of immune cells in PDAC patients and may also affect how the tumor interacts with these immune cells, suggesting that improving gut health could help fight PDAC better.
Background: Galectins (Gal's) are a family of carbohydrate-binding proteins that are known to support the tumour microenvironment through their immunosuppressive activity and ability to promote metastasis. As such they are attractive therapeutic targets, but little is known about the cellular expression pattern of galectins within the tumour and its neighbouring stromal microenvironment. Here we investigated the cellular expression pattern of Gals within pancreatic ductal adenocarcinoma (PDAC).
View Article and Find Full Text PDFPancreatic ductal adenocarcinoma has a poor clinical outcome and responses to immunotherapy are suboptimal. Stromal fibroblasts are a dominant but heterogenous population within the tumor microenvironment and therapeutic targeting of stromal subsets may have therapeutic utility. Here, we combine spatial transcriptomics and scRNA-Seq datasets to define the transcriptome of tumor-proximal and tumor-distal cancer-associated fibroblasts (CAFs) and link this to clinical outcome.
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