Publications by authors named "S E M Ten Holter"
Article Synopsis
- The lncRNA Crossfirre is an X-linked gene that is transcribed opposite to another lncRNA called Firre, and together with Dxz4, they form significant chromatin structures specific to inactive X chromosomes.
- Researchers carried out large-scale knockout studies of Crossfirre, Firre, and Dxz4 to understand their in vivo roles, finding that although these loci have unique epigenetic traits, they are not crucial for X chromosome inactivation processes.
- The study reveals that Crossfirre influences the regulation of autosomal genes, but only in conjunction with Firre, and includes a phenotyping analysis that highlights various knockout and sex-specific outcomes.
Thyroid hormone (TH) effects are mediated through TH receptors (TRs), TRα1, TRβ1, and TRβ2. The TRs bind to the DNA and regulate expression of TH target genes (canonical signaling). In addition, they mediate activation of signaling pathways (noncanonical signaling).
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- Circular RNAs (circRNAs) are noncoding RNAs, and many have unknown biological functions due to challenges in studying them.
- This study specifically investigated circTulp4, a circRNA found in the brain, by creating a mouse model that lacks circTulp4 while preserving normal mRNA and protein levels.
- The findings show that circTulp4 is essential for proper brain function, influencing neurotransmission and responses to negative stimuli, highlighting the importance of circRNAs in neural regulation.