Chemoproteomic Profiling of for Characterization of Anti-fungal Kinase Inhibitors.

is a growing health concern as the leading causal agent of systemic candidiasis, a life-threatening fungal infection with a mortality rate of ∼40% despite best available therapy. Yck2, a fungal casein kinase 1 (CK1) family member, is the cellular target of inhibitors YK-I-02 (YK) and MN-I-157 (MN). Here, multiplexed inhibitor beads paired with mass spectrometry (MIB/MS) employing ATP-competitive kinase inhibitors were used to define the selectivity of these Yck2 inhibitors across the global proteome.

Use of Degludec in Youth With Type 1 Diabetes and Recurrent Diabetic Ketoacidosis.

This article describes a pediatric diabetes center quality improvement initiative to switch youth with type 1 diabetes and diabetic ketoacidosis (DKA) from insulin glargine to longer-duration insulin degludec to determine whether this change would reduce DKA recurrence. Overall, the change in DKA recurrence with degludec was not statistically significant. However, subgroup analysis showed that race/ethnicity and insurance status were significantly associated with change in DKA rates.

Inclined distance running at iso-efficient speeds: Effect on joint work.

Runners often reduce their pace during inclined running to maintain a constant metabolic workload, known as iso-efficiency speed (a speed-incline combination with the same metabolic intensity as level running). This study investigates changes in lower extremity (LE) joint work profiles when running on an incline at iso-efficiency speed. Eleven collegiate distance runners completed a treadmill running task under three conditions (0%, 4%, and 8% incline).

The Use of HIV Prevention Strategies and Services Reported by Black Women with a Risk for and with HIV in the United States.

Black women are disproportionately affected by HIV. We analyzed data from two Centers for Disease Control and Prevention's HIV surveillance systems to better understand HIV prevention strategies used by Black women at risk for and with HIV to help inform efforts to end HIV. Among sexually active Black women, we analyzed 2019 National HIV Behavioral Surveillance data on women without HIV (n = 4,033) and 2018-2020 Medical Monitoring Project data on women with HIV (n = 967).