Metal-(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple-Negative Breast Cancer.

Invited for the cover of this issue are Tatiyana Serebryanskaya, Mikhail Kinzhalov and co-workers at St. Petersburg State University, the Research Institute for Physical Chemical Problems, Belarusian State University, Togliatti State University and Blokhin National Medical Research Center of Oncology. The image depicts the shield of Pallas Athena with the structure of a palladium carbene complex that protects against triple-negative breast cancer.

Metal-(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple-Negative Breast Cancer.

Hydrolytically stable Pd and Pt complexes supported by acyclic diaminocarbene ligands represent a novel class of structural organometallic anticancer agents exhibiting nanomolar antiproliferative activity in a panel of cancer cell lines (IC 0.07-0.81 μM) and up to 300-fold selectivity for cancer cells over normal primary fibroblasts.

Mutual Placement of Isocyanide and Phosphine Ligands in Platinum(II) Complexes [PtHalLL] (Hal = Cl, Br, I; L,L = CNCy, PPh) Leads to Highly-Efficient Photocatalysts for Hydrosilylation of Alkynes.

A series of platinum complexes featuring phosphine and isocyanide ligands [PtX(PPh)(CNCy)] (X = Cl, Br, and I) as well as their parent phosphine [PtX(PPh)] and isocyanide [PtX(CNCy)] analogues have been prepared and evaluated as catalysts for the photocatalytic hydrosilylation of alkynes. Under violet light irradiation (λ = 400 nm), phosphine-isocyanides complexes [PtX(PPh)(CNCy)] gave high yields of silylated products (product yield up to 99%, TONs up to 1.98 × 10).

Cyclometalated platinum(II) complexes with acyclic diaminocarbene ligands for OLED application.

A novel series of cyclometalated platinum(II) complexes bearing acyclic diaminocarbene (ADC) ancillary ligands were designed and prepared. Their photophysical properties were systematically studied through experimental and theoretical investigations. All complexes exhibit green phosphorescence with a quantum efficiency of up to 45% in 2 wt% doped PMMA film at room temperature.