Publications by authors named "S E Huttmann"
Background: The spontaneous breathing trial (SBT) is a well-established diagnostic test for predicting extubation failure in intubated intensive care unit (ICU) patients. However, the SBT has not been evaluated in a specific cohort of tracheostomized patients in whom weaning is prolonged and ultimately unsuccessful.
Objective: The aim of the trial was to investigate the relevance of SBT failure criteria in chronic respiratory failure subjects undergoing long-term invasive home mechanical ventilation following tracheostomy and weaning failure.
Article Synopsis
- The study investigates factors influencing the success of prolonged weaning in tracheotomised patients, highlighting significant variability in outcomes among this diverse patient group.
- A retrospective analysis of 124 patients revealed that approximately 48.4% were successfully weaned, with several predictors identified through statistical assessments, such as the timing of spontaneous breathing trials and PaCO2 levels.
- The findings suggest that specific clinical indicators, particularly related to respiratory insufficiency type II, can effectively predict weaning success or failure, emphasizing the importance of early intervention and patient monitoring.
Background: Health-related quality of life (HRQL), life satisfaction, living conditions, patients' attitudes towards life and death, expectations, beliefs and unmet needs are all poorly understood aspects associated with patients receiving invasive home mechanical ventilation (HMV) following ICU treatment and unsuccessful weaning. Therefore, the present study aimed to assess (1) HRQL, (2) life satisfaction and (3) patients' perspectives on life and death associated with invasive HMV as the consequence of unsuccessful weaning.
Results: Patients undergoing invasive HMV with full technical supply and maximal patient care were screened over a 1-year period and assessed in their home environment.
The culture supernatant of Caldariomyces fumago strains grown in a minimal medium with fructose contains mainly the biotechnologically relevant enzyme chloroperoxidase (CPO) and only minor amounts of other proteins. Our approach to identify the nature of these proteins via peptide mass fingerprinting and transcriptome analysis demonstrated the presence of putative glycosyl hydrolase and glucose oxidase (GOx) enzymes. These activities had been described earlier as parts of the fungus´ halogenation machinery, as they provide CPO with the co-substrate HO.
View Article and Find Full Text PDFBackground And Objective: Continuous partial pressure of carbon dioxide (PCO ) assessment is essential for the success of mechanical ventilation (MV). Non-invasive end-tidal PCO (PetCO ) and transcutaneous PCO (PtcCO ) measurements serve as alternatives to the gold standard arterial PCO (PaCO ) method, but their eligibility in critical care is unclear.
Methods: The present study therefore performed methodological comparisons of PaCO versus PetCO and PtcCO , respectively, in weaning patients receiving invasive MV via tracheal cannulas.