Publications by authors named "S E Huggins"
Our aim is to propose a framework for the development of a research case definition of lipedema, based on current available literature and those observations that can be applied to future lipedema research with the intent to standardize and strengthen the scientific evidence base. We conducted a narrative review of the literature, and identified consensus characteristics and disputed characteristics that could be included in a research case definition of lipedema. After considering the strength of the evidence and how each characteristic might be measured in a research study, we recommended an approach for the development of a research case definition of lipedema that would be based on consideration of five agreed-upon characteristics, and five disputed, or less substantiated, characteristics as additional evidence to enhance specificity.
View Article and Find Full Text PDFBackground: Undiagnosed Type 2 diabetes (T2D) has been associated with advanced stage cancer at diagnosis, higher mortality, and lower long-term all-cause survival. This was a RCT pilot study to examine the feasibility of a nurse-led T2D intervention for adults with newly diagnosed cancer (≤3 months), and T2D, undiagnosed or untreated with medication, conducted at an outpatient oncology clinic affiliated with a large academic institution.
Methods: Participants needed to meet the eligibility criteria including a HbA1c level between 6.
Article Synopsis
- The study focused on understanding the health information-seeking behavior (HISB) of college students, particularly in light of their increasing independence and personal health decision-making.
- The research involved surveying 226 undergraduate students at a diverse public institution in New York City, examining the sources they use for health information and how demographic factors influence their behavior.
- Key findings indicated that students' beliefs about online health information accuracy and the number of followers a health provider has on social media significantly impacted their HISB, emphasizing the need for educational programs to improve students' health information literacy.
Hypophosphatasia (HPP) is the inherited error-of-metabolism caused by mutations in ALPL, reducing the function of tissue-nonspecific alkaline phosphatase (TNAP/TNALP/TNSALP). HPP is characterized by defective skeletal and dental mineralization and is categorized into several clinical subtypes based on age of onset and severity of manifestations, though premature tooth loss from acellular cementum defects is common across most HPP subtypes. Genotype-phenotype associations and mechanisms underlying musculoskeletal, dental, and other defects remain poorly characterized.
View Article and Find Full Text PDFShort-term hyper-caloric high-fat feeding on a ketogenic diet can lower low-density lipoprotein cholesterol: the cholesterol drop experiment.
Curr Opin Endocrinol Diabetes Obes
October 2022
Article Synopsis
- The conventional belief links saturated fat intake to increased LDL-C levels, especially in individuals on low-carb, high-fat diets, but this perspective doesn't fully explain certain lipid patterns.
- The Lipid Energy Model (LEM) offers a new explanation for LDL-C increases in 'lean mass hyper-responders' and predicts that acute overfeeding should lower LDL-C, even with higher saturated fat intake.
- A recent study and case series demonstrated that short-term overfeeding on ketogenic diets led to decreased LDL-C levels, aligning with the predictions of the LEM.