Two new species of . and , are formally described from eastern and midwestern North America based on molecular data, morphological characters and geographic distribution pattern. They are found in summer and fall in hardwood forests including (, ) and in grassy clearings and nutrient-rich soils.
View Article and Find Full Text PDFIntroduction: The impact of cyberbullying victimization on youth development, encompassing mental health, academic performance, and socioemotional well-being, has been widely documented. Research highlights the heightened vulnerability of sexual and gender minoritized youth, along with other youth from marginalized groups, to cybervictimization. However, there is a gap in understanding how intersecting marginalized social identities affect experiences of cyberbullying.
View Article and Find Full Text PDFReproductive success requires accurately timed remodeling of the cervix to orchestrate the maintenance of pregnancy, the process of labor, and birth. Prior work in mice established that a combination of continuous turnover of fibrillar collagen and reduced formation of collagen cross-links allows for the gradual increase in tissue compliance and delivery of the fetus during labor. However, the mechanism for continuous collagen degradation to ensure turnover during cervical remodeling is still unknown.
View Article and Find Full Text PDFConventional pelvic exenteration (PE) comprises the removal of all or most central pelvic organs and is established in clinical practise. Previously, tumours involving bone or lateral sidewall structures were deemed inoperable due to associated morbidity, mortality, and poor oncological outcomes. Recently however high-complexity PE is increasingly described and is defined as encompassing conventional PE with the additional resection of bone or pelvic sidewall structures.
View Article and Find Full Text PDFBackground: The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical studies have implicated macrophage-mediated immune tolerance. Hence, pathways that regulate macrophage phenotype are of strategic interest, with reprogramming strategies focusing on inhibitors of phosphoinositide 3-kinase-gamma (PI3Kγ) due to restricted immune cell expression. Inhibition of PI3Kγ alone is ineffective in PDAC, despite increased infiltration of CD8+ T cells.
View Article and Find Full Text PDF