Bayesian plasma model selection for Thomson scattering.

Laser Thomson scattering (LTS) is a measurement technique that can determine electron velocity distribution functions in plasma systems. However, accurately inferring quantities of interest from an LTS signal requires the selection of a plasma physics submodel, and comprehensive uncertainty quantification (UQ) is needed to interpret the results. Automated model selection, parameter estimation, and UQ are particularly challenging for low-density, low-temperature, potentially non-Maxwellian plasmas like those created in space electric propulsion devices.

T-bet B cells are activated by and control endogenous retroviruses through TLR-dependent mechanisms.

Endogenous retroviruses (ERVs) are an integral part of the mammalian genome. The role of immune control of ERVs in general is poorly defined as is their function as anti-cancer immune targets or drivers of autoimmune disease. Here, we generate mouse-strains where Moloney-Murine Leukemia Virus tagged with GFP (ERV-GFP) infected the mouse germline.

PBPK-PD modeling for the preclinical development and clinical translation of tau antibodies for Alzheimer's disease.

Disrupted tau proteostasis and transneuronal spread is a pathological hallmark of Alzheimer's disease. Neurodegenerative diseases remain an unmet medical need and novel disease modifying therapeutics are paramount. Our objective was to develop a mechanistic mathematical model to enhance our understanding of tau antibody pharmacokinetics and pharmacodynamics in animals and humans.

Megahertz-rate background-oriented schlieren tomography in post-detonation blasts.

The understanding and predictive modeling of explosive blasts require advanced experimental diagnostics that can provide information on local state variables with high spatiotemporal resolution. Current datasets are predominantly based on idealized spherically symmetric explosive charges and point-probe measurements, although practical charges typically involve multidimensional spatial structures and complex shock-flow interactions. This work introduces megahertz-rate background-oriented schlieren tomography to resolve transient, three-dimensional density fields, as found in an explosive blast, without symmetry assumptions.

CellCelector™ as a platform in isolating primary B cells for antibody discovery.

The most robust strategy in antibody discovery is the use of immunized animals and the ability to isolate and immortalize immune B-cells to hybridoma for further interrogation. However, capturing the full repertoire of an immunized animal is labor intensive, time consuming and limited in throughput. Therefore, techniques to directly mine the antibody repertoire of primary B-cells are of great importance in antibody discovery.