Deroofing: A safe, effective and well-tolerated procedure in patients with hidradenitis suppurativa.

Introduction: Hidradenitis suppurativa (HS) is a recurrent, debilitating, chronic disorder of the pilosebaceous unit. Although advances in HS treatment have been made, more than 45% of patients remain dissatisfied with systemic treatment, and more than one-third are dissatisfied with surgical procedures.

Objectives: A prospective, observational study on the deroofing procedures in HS with special attention paid to patient satisfaction and complications.

Unraveling Signatures of Local Adaptation among Indigenous Groups from Mexico.

Few studies have addressed how selective pressures have shaped the genetic structure of the current Native American populations, and they have mostly limited their inferences to admixed Latin American populations. Here, we searched for local adaptation signals, based on integrated haplotype scores and population branch statistics, in 325 Mexican Indigenous individuals with at least 99% Native American ancestry from five previously defined geographical regions. Although each region exhibited its own local adaptation profile, only and , both negative regulators of the Wnt/β catenin signaling pathway, showed significant adaptation signals in all the tested regions.

Genotypes and Haplotypes in the and Genes are Associated With Susceptibility and With Clinicopathological Characteristics in Breast Cancer Patients.

Breast cancer is a multifactorial disease whose genetic susceptibility is related to polymorphic variants of cell proliferation and migration pathways. Variants in and in the Wnt-β catenin pathway have been associated with different types of cancer; however, little is known about its role in breast cancer. This study tests the hypothesis of links between rs1133683 and rs2240308, and rs7903146 and rs12255372 variants in breast cancer.

variants rs3826392 and rs3809728 are associated with susceptibility and clinicopathological features in colorectal cancer patients.

Objectives: The mitogen-activated protein kinase kinase 4 () plays a key role in several processes like inflammation, apoptosis, and tumorigenesis. Several authors have proposed that genetic variations in these genes may alter their expression with subsequent cancer risk. This study aimed to examine the possible association of rs3826392 and rs3809728 variants in Mexican patients with colorectal cancer (CRC).