Publications by authors named "S E Espinoza"
Article Synopsis
- Loss-of-function mutations in the CHD8 gene are linked to Autism Spectrum Disorders (ASD), leading to significant molecular and cellular changes relevant for developing new therapies.
- Synthetic SINEUP-CHD8, a type of long non-coding RNA, can increase the production of the CHD8 protein in cells lacking it, and reverse associated negative effects in cells from patients with CHD8 mutations.
- In zebrafish models, SINEUP-CHD8 not only alleviated symptoms caused by CHD8 suppression, like macrocephaly and excessive neuron production, but also suggests potential for RNA-based treatments for various neurodevelopmental disorders.
Physical activity (PA) and its contributions to wellbeing are understudied among incarcerated youth. We used 2019 Minnesota Student Survey data to describe PA rates and test PA's associations with indicators of psychological, social, and perceived health for adolescents in juvenile corrections facilities (JCFs). Participants ( = 265, 29% female, = 15.
View Article and Find Full Text PDFWe report the first application of broadband time-resolved pump-probe ellipsometry to study the ultrafast dynamics of the photoinduced insulator-to-metal transition (IMT) in vanadium dioxide (VO) thin films driven by 35 fs laser pulses. This novel technique enables the direct measurement of the time-resolved evolution of the complex pseudodielectric function of VO during the IMT. We have identified distinct thermal and nonthermal dynamics in the photoinduced IMT, which critically depends on the pump wavelength and fluence, while providing a detailed temporal and spectral phase map.
View Article and Find Full Text PDFDescription Of The Cases: A series of 6 cases with a probable diagnosis of sporadic CJD, treated in a Peruvian national reference hospital, are presented.
Clinical Findings: The relevant clinical signs were rapidly progressive dementia and myoclonus, followed by akinetic mutism and pyramidal signs.
Treatment And Results: Of the cases presented, 80% were men, with an average age of presentation of 65 years and duration from diagnosis to death of 6.
Article Synopsis
- The study explored how slow gait speed and weak handgrip strength in older adults are linked to an increased risk of developing depression over time.
- It utilized data from a large group of participants (17,231) over approximately 4 years, measuring depression through a validated self-reported scale.
- Findings indicate that both low physical performance measures are significant risk factors for depression, suggesting the importance of addressing physical health to improve mental well-being in older adults.