Identification of βIIΣ1-spectrin as a binding partner of the GH-regulated human obesity scaffold protein SH2B1.

SH2B1β is a multifunctional scaffold protein that modulates cytoskeletal processes such as cellular motility and neurite outgrowth. To identify novel SH2B1β-interacting proteins involved in these processes, a yeast two-hybrid assay was performed. The C-terminal 159 residues of the cytoskeleton structural protein, βIIΣ1-spectrin, interacted with the N-terminal 260 residues of SH2B1β, a region implicated in SH2B1β enhancement of cell motility and localization at the plasma membrane.

Hypoxic Pulmonary Vasoconstriction: An Important Component of the Homeostatic Oxygen Sensing System.

Hypoxic pulmonary vasoconstriction (HPV) rapidly and reversibly matches lung ventilation (V) and perfusion (Q), optimizing oxygen uptake and systemic oxygen delivery. HPV occurs in small pulmonary arteries (PA), which uniquely constrict to hypoxia. Although HPV is modulated by the endothelium the core mechanism of HPV resides in PA smooth muscle cells (PASMC).

The LTAR Grazing Land Common Experiment at Walnut Gulch Experimental Watershed.

The Walnut Gulch Experimental Watershed (WGEW) Long-Term Agroecosystem Research (LTAR) network common experiment addresses the aspirational practice of brush management (BM) to reverse the prevailing condition of woody plant encroachment (WPE) and increase perennial native grass production. Across the western United States, the decision to implement BM includes consideration of management objectives, cost, and the expected impact on a diverse suite of ecosystem services. Maintaining or restoring grass cover will help meet the LTAR sustainable production, economic, and social goals, and averting degradation will meet environmental goals.