Background: Systematic reviews provide clarity of a bulk of evidence and support the transfer of knowledge from clinical trials to guidelines. Yet, they are time-consuming. Artificial intelligence (AI), like ChatGPT-4o, may streamline processes of data extraction, but its efficacy requires validation.
View Article and Find Full Text PDFUsing whole-genome sequencing (WGS) might offer insights into rare genetic variants associated with healthy aging and extreme longevity (EL), potentially pointing to useful therapeutic targets. In this study, we conducted a genome-wide association study using WGS data from the Long Life Family Study and identified a novel longevity-associated variant rs6543176 in the SLC9A2 gene. This SNP also showed a significant association with reduced hypertension risk and an increased, though not statistically significant, cancer risk.
View Article and Find Full Text PDFA number of studies have tested the factor structure of the suggested ICD-11 symptom criteria for PTSD and complex PTSD (CPTSD) across various trauma populations, finding support for two different models in line with the ICD-11 theoretical rationale. Here, we aim to explore the factor structure of the Danish version of the International Trauma Questionnaire (ITQ) by testing two alternative factor models that have previously gained support in a large sample of treatment-seeking veterans. Treatment-seeking Danish soldiers and veterans ( = 599) recruited from the Military Psychology Department in the Danish Defence completed the International Trauma Questionnaire (ITQ).
View Article and Find Full Text PDFIntroduction: Tumor-infiltrating lymphocytes are both prognostic and predictive biomarkers for immunotherapy response. However, less is known about the survival benefits oftheir subpopulations.
Methods: Using machine learning models, we assessed the clinical association of the CD8+, PD1+, TCF1+ cel l subset by multiplex immunohistochemistry using tissue microarrays in 553 non-small cell lung cancer (NSCLC) patients and its correlation with other immune cell biomarkers.