Publications by authors named "S Durgamma"
Chiral amino acid-derived formamides represent one of the most versatile components in multicomponent reactions. Herein, we describe a facile synthesis of N-protected amino sulfenyl methyl formamides and sulfonyl methyl formamides the Mannich reaction of N-protected amino alkyl thiols followed by oxidation using 3-chloroperbenzoic acid (-CPBA). This protocol is applicable to a wide range of Fmoc- and Cbz-protected amino acids.
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- A new method has been developed to create Nβ-protected amino alkyl isothiocyanates using Nβ-protected amino alkyl azides through a Staudinger/aza-Wittig reaction.
- The approach avoids complications with labile groups in amino acid chemistry and allows for easier precursor preparation, while keeping protective groups intact.
- This technique is efficient as it bypasses the need for amines, maintains chirality, and simplifies the handling and purification of the resulting compounds, some of which were previously unreported.