Antibacterial and surface properties of post-light-activated metal-free phthalocyanine-deposited TiO nanotube smart surfaces.

The utilisation of implantable medical devices has become safer and more prevalent since the establishment of sterilisation methods and techniques a century ago. Nevertheless, device-associated infections remain a significant and growing concern, particularly in light of the continued rise in the number of medical device implantations. This underscores the imperative for the development of efficacious prevention and treatment strategies for device-associated infections, as well as further investigation into the design of innovative antibacterial surfaces for medical device applications.

Surface characterization and antibacterial efficiency of well-ordered TiO nanotube surfaces fabricated on titanium foams.

Titanium (Ti)-based implants are not compatible enough due to their bio-inert character, insufficient antibacterial capabilities and stress-shielding problem for dental and orthopaedic implant applications. Thus, this work focused to fabricate, analyze and improve antibacterial properties titanium dioxide (TiO) nanotube array surfaces on Ti foam by anodic oxidation (AO) process. The well-ordered nanotube arrays with approximately 75 nm were successfully fabricated at 40 V for 1 h on Ti foams.

Readout of histone methylation by Trim24 locally restricts chromatin opening by p53.

The genomic binding sites of the transcription factor (TF) and tumor suppressor p53 are unusually diverse with regard to their chromatin features, including histone modifications, raising the possibility that the local chromatin environment can contextualize p53 regulation. Here, we show that epigenetic characteristics of closed chromatin, such as DNA methylation, do not influence the binding of p53 across the genome. Instead, the ability of p53 to open chromatin and activate its target genes is locally restricted by its cofactor Trim24.

Characterization and investigation of biological properties of silver nanoparticle-doped hydroxyapatite-based surfaces on zirconium.

The infections leading to failed implants can be controlled mainly by metal and metal oxide-based nanoparticles. In this work, the randomly distributed AgNPs-doped onto hydroxyapatite-based surfaces were produced on zirconium by micro arc oxidation (MAO) and electrochemical deposition processes. The surfaces were characterized by XRD, SEM, EDX mapping and EDX area and contact angle goniometer.