[Visions and repercussions of identity-release in oocyte and sperm donors : descriptive survey among gamete donors].

Objectives: The Bioethics Law of August 2nd, 2021 established access to origins for people conceived by gamete donation. Two years after the implementation of this disposition, what is the proportion of former gamete donors informed about access to origins, and what is their position on this matter? What could be the potential repercussions of this new law on them? .

Methods: Retrospective single-center cohort study using questionnaires Results: When former gamete donors were asked about access to origins, only 53 % of oocytes donors and 71 % of sperm donors were aware of this measure.

Vitamin D and/or calcium to prevent fractures and falls: protocol for a systematic review and meta-analysis.

Background: Previous systematic reviews on fracture and fall prevention have generally shown no efficacy with calcium or vitamin D alone and conflicting findings with that of vitamin D combined with calcium. Despite these findings, increases in vitamin D and calcium prescriptions have been reported in many countries, as many clinicians, guidelines and regulatory agencies still largely recommend universal supplementation to adults.

Methods And Analysis: We will conduct a systematic review of randomised controlled trials on the efficacy of vitamin D and/or calcium in fracture and fall prevention.

Metaphor as methodology: Methodological reflections on visualizing the dementia journey.

Metaphors to describe and understand dementia have been used in Western culture for many years. However, the ways in which people living with dementia and care partners use metaphors and symbols to illustrate and give meaning to their own experiences has been less understood. In this paper we explore the use of metaphor as methodology-- a way to support people living with dementia and their care partners in reflecting on and sharing their experiences of dementia.

Scarcity of fixed carbon transfer in a model microbial phototroph-heterotroph interaction.

Although the green alga Chlamydomonas reinhardtii has long served as a reference organism, few studies have interrogated its role as a primary producer in microbial interactions. Here, we quantitatively investigated C. reinhardtii's capacity to support a heterotrophic microbe using the established coculture system with Mesorhizobium japonicum, a vitamin B12-producing α-proteobacterium.

The lack of Tex44 causes severe subfertility with flagellar abnormalities in male mice.

By analyzing a mouse Interspecific Recombinant Congenic Strain (IRCS), we previously identified a quantitative trait locus (QTL), called Mafq1 on mouse chromosome 1, that is associated with male hypofertility and ultrastructural sperm abnormalities. Within this locus, we identified a new candidate gene that could be implicated in a reproductive phenotype: Tex44 (Testis-expressed protein 44). We thus performed a CRISPR/Cas9-mediated complete deletion of this gene in mice in order to study its function.