Publications by authors named "S Dulong"
Article Synopsis
- Scientists are working on a way to better understand how drugs like oxaliplatin work in humans by using information from animal studies and lab tests.
- They created a model that compares how the drug is distributed in the blood of mice, rats, and humans, which helped them predict how it works in people.
- The team's new method allowed them to make sure their model was accurate, and they want to try this approach with other drugs in the future to improve treatments.
Oxaliplatin was nearly twice as hematotoxic, with optimal circadian timing differing by 6 h, in women as compared to men with colorectal cancers. Hence, we investigated sex- and timing-related determinants of oxaliplatin hematopoietic toxicities in mice. Body-weight loss (BWL), blood cell counts, bone marrow cellularity (BMC) and seven flow-cytometry-monitored hematopoietic progenitor populations were evaluated 72 h after oxaliplatin chronotherapy administration (5 mg/kg).
View Article and Find Full Text PDFUrinary levels of modified nucleosides reflect nucleic acids turnover and can serve as non-invasive biomarkers for monitoring tumour circadian dynamics, and treatment responses in patients with metastatic colorectal cancer. In 39 patients, median overnight urinary excretion of LC-HRMS determinations of pseudouridine, was ~ tenfold as large as those of 1-methylguanosine, 1-methyladenosine, or 4-acetylcytidine, and ~ 100-fold as large as those of adenosine and cytidine. An increase in any nucleoside excretion after chemotherapy anticipated plasma carcinoembryonic antigen progression 1-2 months later and was associated with poor survival.
View Article and Find Full Text PDFMotivation: Personalized medicine aims at providing patient-tailored therapeutics based on multi-type data toward improved treatment outcomes. Chronotherapy that consists in adapting drug administration to the patient's circadian rhythms may be improved by such approach. Recent clinical studies demonstrated large variability in patients' circadian coordination and optimal drug timing.
View Article and Find Full Text PDFArticle Synopsis
- Breast cancer is the most prevalent cancer globally and a leading cause of cancer deaths among women, with studies linking night-shift work and circadian disruption to increased cancer risk.
- The research uses a mouse model to explore how chronic jetlag affects mammary tumor development, revealing that circadian disruption accelerates cancer spread and alters the tumor environment.
- The findings suggest that using a CXCR2 inhibitor may help counteract the negative effects of chronic circadian disruption on breast cancer progression.