Publications by authors named "S Dukic"
We have investigated the impact of gemcitabine (Gem) and deuterated gemcitabine-squalene (GemSQ-d6) nanoparticles (NPs) on MCF7 and MDA-MB-231 breast cancer cell lines by Raman spectroscopy. Quantification of LDL expression levels in both cell lines revealed a four-fold increase in MDA-MB-231 cells compared to MCF7 cells. In in vitro antitumor assessments, Gem displayed 13.
View Article and Find Full Text PDFAmyotrophic lateral sclerosis (ALS) is characterised primarily by motor system degeneration, with clinical evidence of cognitive and behavioural change in up to 50% of cases. We have shown previously that resting-state EEG captures dysfunction in motor and cognitive networks in ALS. However, the longitudinal development of these dysfunctional patterns, especially in networks linked with cognitive-behavioural functions, remains unclear.
View Article and Find Full Text PDFBackground And Purpose: Resting-state electroencephalography (EEG) holds promise for assessing brain networks in amyotrophic lateral sclerosis (ALS). We investigated whether neural β-band oscillations in the sensorimotor network could serve as an objective quantitative measure of progressive motor impairment and functional disability in ALS patients.
Methods: Resting-state EEG was recorded in 18 people with ALS and 38 age- and gender-matched healthy controls.
Recent electroencephalography (EEG) studies have shown that patterns of brain activity can be used to differentiate amyotrophic lateral sclerosis (ALS) and control groups. These differences can be interrogated by examining EEG microstates, which are distinct, reoccurring topographies of the scalp's electrical potentials. Quantifying the temporal properties of the four canonical microstates can elucidate how the dynamics of functional brain networks are altered in neurological conditions.
View Article and Find Full Text PDFArticle Synopsis
- Primary lateral sclerosis (PLS) is a condition where important brain cells, called upper motor neurons, gradually stop working properly, mostly affecting movement.
- This study looked at how the brain and muscles communicate during a hand task in people with PLS compared to healthy individuals, using special tools to measure brain activity (EEG) and muscle activity (EMG).
- The results showed unusual patterns of brain and muscle interaction in PLS patients, suggesting that their brains might be trying to adapt to the disease, which could help understand how PLS affects movement.