Publications by authors named "S Dremier"
Identification of improved translatable biomarkers of nephrotoxicity is an unmet safety biomarker need. Fatty-acid-binding protein 4 (FABP4) was previously found to be associated with clinical renal dysfunction and was proposed as a biomarker of glomerular damage. The aim of this study was to evaluate FABP4 as a potential preclinical biomarker of drug-induced kidney injury (DIKI).
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- Drug-induced kidney injury (DIKI) is a major issue in drug development, and traditional urinary protein biomarkers have limitations, prompting interest in microRNAs (miRNAs) as potential alternatives.
- In a study involving Wistar rats treated with three nephrotoxic substances, specific miRNAs were found to be significantly dysregulated, indicating their potential as biomarkers for kidney injury targeting different nephron segments.
- The findings suggest that combining urinary miRNAs with protein biomarkers could improve the detection of kidney damage during drug testing, enhancing our understanding of DIKI in preclinical studies.
Rationale: Impulsive-compulsive disorders (ICD) in patients with Parkinson's disease (PD) have been described as behavioral or substance addictions including hypersexuality, gambling, or compulsive medication use of the dopamine replacement therapy (DRT).
Objectives: A remaining challenge is to understand the neuroadaptations leading to reward bias in PD patients under DRT.
Methods: To this end, the appetitive effect of the D2/D3 agonist pramipexole was assessed after chronic exposure to L-dopa in an alpha-synuclein PD rat model.
The mechanisms of action of modafinil continue to be poorly characterised and its potential for abuse in preclinical models remains controverted. The aim of this study was to further elucidate the mechanism of action of modafinil, through a potential behavioural and molecular association in the mouse. A conditioned place preference (CPP) paradigm was implemented to investigate the rewarding properties of modafinil.
View Article and Find Full Text PDFDrug-induced cardiac injury (DICI) detection remains a major safety issue in drug development. While circulating microRNAs (miRs) have emerged as promising translational biomarkers, novel early detection biomarkers of cardiotoxicity are needed. This work aims at evaluating whether a panel of putative cardiac injury plasma miRs could serve as early DICI biomarkers in a 4-day rat preclinical model.
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