Positron emission tomography reveals correlations between brain metabolism and mood changes in hyperthyroidism.

Context: Hyperthyroidism is frequently associated with emotional distress. The underlying cerebral processes of the endocrine-induced mood changes are unclear.

Objective: The objective of this study was to investigate, for the first time, the neuronal correlates of thyrotoxicosis-associated psychic symptoms using positron emission tomography (PET).