Publications by authors named "S Dotti"
The Abnormal Toxicity Test (ATT) is an in vivo assay traditionally used in the autogenous vaccine release. That test, commonly applied to verify vaccine quality, is subject to ethical and practical limitations and should be removed as reference methods. This approach is necessary to update the regulatory framework and to apply the 3Rs principle in the pharmaceutical field.
View Article and Find Full Text PDFBackground: Advanced Hybrid Closed-Loop system (AHCL) has profoundly changed type 1 diabetes therapy. This study primarily aimed to assess the impact on Glycemia Risk Index (GRI) and other continuous glucose monitoring (CGM) metrics when switching from one of four insulin strategies to AHCL in type 1 adult patients.
Methods: A single-center, retrospective pre/post observational study; 198 patients (age 44.
Article Synopsis
- The shortage of human organs for transplantation has led to increased interest in using pig organs (xenotransplantation) as a potential solution, but concerns about infectious agents like Pig Endogenous Retroviruses (PERVs) pose significant risks.
- Research indicates that PERVs are widespread in various swine cell lines and tissue samples, found in all established cell lines, 40% of primary cell lines, and 60% of tested tissue samples.
- The study demonstrated that PERVs can infect human cells, raising serious safety concerns and highlighting the need for further research to address these issues before xenotransplantation can be deemed microbiologically safe.
The process of identifying and approving a new drug is a time-consuming and expensive procedure. One of the biggest issues to overcome is the risk of hepatotoxicity, which is one of the main reasons for drug withdrawal from the market. While animal models are the gold standard in preclinical drug testing, the translation of results into therapeutic intervention is often ambiguous due to interspecies differences in hepatic metabolism.
View Article and Find Full Text PDFDue to the recurrent pandemic outbreaks that occurred during the last century, Influenza A viruses are considered a serious potential danger to human health. Among the innate immune pathways in eukaryotes, RNA interference plays a significant role in the interaction between viruses and host cells. RNA interference is addressed by small dsRNA molecules produced by the host itself (miRNAs, i.
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