Publications by authors named "S Done"
Background: Visualization of cancer during breast conserving surgery (BCS) remains challenging; the BCS reoperation rate is reported to be 20-70% of patients. An urgent clinical need exists for real-time intraoperative visualization of breast carcinomas during BCS. We previously demonstrated the ability of a prototype imaging device to identify breast carcinoma in excised surgical specimens following 5-aminolevulinic acid (5-ALA) administration.
View Article and Find Full Text PDFPurpose: Primary Mucosa-associated lymphoid tissue (MALT) lymphoma is a rare diagnosis in the breast, and clinical diagnosis based on radiological features is often challenging. This study aimed to evaluate the clinicopathological, and radiological characteristics of the patients diagnosed with primary breast MALT lymphoma.
Methods: This study examined 18 cases of primary MALT lymphoma of the breast diagnosed at a single tertiary center between January 2002 to December 2020.
Ki-67 is a nuclear protein associated with proliferation, and a strong potential biomarker in breast cancer, but is not routinely measured in current clinical management owing to a lack of standardization. Digital image analysis (DIA) is a promising technology that could allow high-throughput analysis and standardization. There is a dearth of data on the clinical reliability as well as intra- and interalgorithmic variability of different DIA methods.
View Article and Find Full Text PDFThe Ki-67 proliferation index (PI) guides treatment decisions in breast cancer but suffers from poor inter-rater reproducibility. Although AI tools have been designed for Ki-67 assessment, their impact on pathologists' work remains understudied. 90 international pathologists were recruited to assess the Ki-67 PI of ten breast cancer tissue microarrays with and without AI.
View Article and Find Full Text PDFArticle Synopsis
- A study analyzed healthcare costs and resource use for nearly 645,000 women aged 50-74 in the Ontario Breast Screening Program between 2011-2014, looking at different screening frequencies and outcomes.
- Results showed that women aged 60-74 incurred the highest average costs, particularly with annual screenings linked to family or personal history, totaling CAD 5425.
- Although annual screenings for women with dense breasts led to higher costs per breast cancer diagnosis, they also had lower costs per false positive compared to biennial screenings, indicating a need for careful resource allocation in breast cancer screening programs.