Publications by authors named "S Dodic"
Background: Although repeatedly confirmed, the molecular nature of gene-environment (GxE) interactions has rarely been investigated in the clinical context of mood disorders. This study assesses the relationship between HTR2A genetic variants and the modulatory effect of inflammation in a collective cohort of patients with major depressive disorder (MDD) and bipolar disorder (BD), as a unified group with two distinct phenotypes.
Methods: The study included 138 patients with acute mood episodes (BD = 83; MDD = 55).
Article Synopsis
- Psychotic and mood disorders are interconnected, suggesting that they may exist on a continuum rather than as separate categories.
- A study on 143 patients with schizophrenia and bipolar disorder revealed that lower levels of the cytokine TGF-β were linked to more severe symptoms and a higher likelihood of psychotic episodes.
- The findings suggest that immune dysregulation, particularly involving TGF-β, could play a shared role in both disorders, which may influence how we classify and understand their clinical presentations.
Increased immune-inflammatory activation has been repeatedly linked to etiopathogenesis and the progression of both major depressive disorder (MDD) and bipolar depression (BD). We explore the role of soluble intercellular cell adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in diagnostic differentiation and disorder progression in patients with MDD and BD. Serum levels of sICAM-1 and sVCAM-1 were measured in 137 patients (MDD = 93 and BD = 44) and compared with 73 healthy controls.
View Article and Find Full Text PDFThe importance and interest in the efficient use and valorization of agro-industrial residues and by-products have grown due to environmental problems associated with improper disposal. Biotechnological production processes, including microbial biosurfactant production, represent a sustainable way to utilize agro-industrial residues and by-products, which are applied as substrates in these processes. Biosurfactants produced by microorganisms using renewable resources are a viable alternative to traditional petrochemical surfactants and have several potential uses in a wide range of industrial sectors due to their minimal ecotoxicity, easy biodegradability, and moderate production conditions.
View Article and Find Full Text PDFAims: In order to be competitive on the market, the production of biopreparations needs to be optimized, modelled, and assessed in the early stages of its development. The aim of this paper was to optimize medium for the production of Trichoderma harzianum K179 biocontrol agent, to analyze its kinetics at enlarged laboratory scale and finally economic analysis of the production of this high-value product through simulation modelling.
Methods And Results: The results showed that the bioprocess of T.