Publications by authors named "S Dodgson"
Neural activity spans multiple time scales, from milliseconds to months. Its evolution can be recorded with chronic high-density arrays such as Neuropixels probes, which can measure each spike at tens of sites and record hundreds of neurons. These probes produce vast amounts of data that require different approaches for tracking neurons across recordings.
View Article and Find Full Text PDFArticle Synopsis
- CRISPR-enabled screening is a technique that helps discover genes affecting T cell function, pointing to potential immunotherapy targets, but there's a need for methods to study specific DNA sequences in these genes.
- A new platform for large-scale base-editing mutagenesis was developed to identify critical nucleotides that influence how T cells react and produce cytokines.
- The research revealed numerous genetic variants in key proteins that can either enhance or diminish T cell function, offering valuable insights for advancing immunotherapy strategies.*
Introduction: Contemporary hemophilia care supports physical activity, its benefits being well recognized. Despite recognition of the psychological challenges encountered by people with hemophilia, little is known about the psychological impact of physical fitness in this population.
Aim: To identify changes in psychological well-being in young men with hemophilia through participation in a gym program.
Introduction: Many young men with hemophilia engage in physical activity and sport but face challenges to participation because of their hemophilia. Project GYM aimed to investigate the feasibility of a hemophilia-specific fitness program led by a personal trainer (PT) and its impact on gym activity, motivation, and adherence to exercise.
Methods: This was a nonblinded, randomized feasibility study, recruiting participants aged 18 to 25 years with hemophilia A or B (all severities, ± inhibitor) from three London hemophilia centers.
Introduction: Nurses play a central co-ordinating role in delivering comprehensive care for people with haemophilia and allied bleeding disorders, for which they need a broad range of competencies. The UK Haemophilia Nurses Association (HNA) published a role description in 1994 which was developed into a competency framework in 2014. This has now been updated to reflect current educational and clinical practice.
View Article and Find Full Text PDF