A bibliometric analysis using a newly developed model and a customizable research tool: A case study of researcher mobility in Sweden.

Researcher mobility is an integral part of the way research is conducted and of a researcher's career. Its effects on collaboration networks, research impact and knowledge flows drive countries and institutions to quantify and understand this activity. The purpose of this study is to test a new researcher mobility model which was developed and prototyped as a customisable research tool to provide a unified perspective on mobility at macro (national), meso (institutional) and micro (individual) levels.

Mitigation of adverse behavioral impact from predator exposure by the nociceptin/orphanin FQ peptide antagonist J-113397 in rats.

The nociceptin/orphanin FQ peptide (NOP) receptor is believed to have an integral modulatory function in the stress response system. We evaluated the highly selective NOP antagonist J-113397 (7.5 and 20.

Switch of sensitivity dynamics revealed with DyGloSA toolbox for dynamical global sensitivity analysis as an early warning for system's critical transition.

Systems with bifurcations may experience abrupt irreversible and often unwanted shifts in their performance, called critical transitions. For many systems like climate, economy, ecosystems it is highly desirable to identify indicators serving as early warnings of such regime shifts. Several statistical measures were recently proposed as early warnings of critical transitions including increased variance, autocorrelation and skewness of experimental or model-generated data.

Pharmacologic modulation of niche accessibility via tyrosine kinase inhibition enhances marrow and thymic engraftment after hematopoietic stem cell transplantation.

Essential survival signals within hematopoietic stem cell (HSC) and thymic niches are mediated by receptor tyrosine kinases, which can be reversibly inhibited using clinically available drugs. We studied whether sunitinib, a multityrosine kinase inhibitor that inhibits KIT, enhances engraftment after bone marrow transplantation (BMT) in mice. Sunitinib diminished hematopoietic progenitor cell numbers, and sunitinib enhanced marrow, peripheral myeloid, and lymphoid engraftment after BMT in Rag1(-/-) mice.

Practical identifiability of photophysical parameters in photodynamic therapy.

Photodynamic therapy (PDT) is an alternative treatment for cancer that involves the administration of a photosensitizing agent, which will be activated by light at a specific wavelength. In order to compare different photosensitisers for their cytotoxic activity, photophysical parameters provide good indicators. These parameters are generally estimated one by one from in vitro dedicated experiments, but they cannot always predict the in vivo cytotoxic action.