Publications by authors named "S Dhooria"
Background: LDBio immunochromatographic lateral flow assay, a point-of care test, detects IgM/IgG antibodies against Aspergillus fumigatus (LDBio-ALFA). LDBio-ALFA has been evaluated for diagnosing chronic pulmonary aspergillosis (CPA) in hospital patients, though its efficacy in field settings remains unexamined.
Objective: Our primary objective was to assess the diagnostic accuracy of LDBio-ALFA in diagnosing CPA in a field and a hospital cohort.
Article Synopsis
- Pleural tuberculosis (pTB) is hard to diagnose due to vague symptoms and limited testing options, prompting the development of a new assay using magnetic nanoparticles and antibodies to detect specific antigens related to the disease.
- The MNp-Ab-Ap assay was created by attaching antibodies to magnetic nanoparticles, enabling the capture of pTB antigens from pleural fluid, which were then identified using specialized aptamers.
- In testing, the MPT51-based variant of the assay showed a sensitivity of 66.6% and a high specificity of 95.4%, proving to be more effective than existing methods like the Xpert MTB/RIF test, suggesting it could significantly improve pTB diagnosis.
Background: The risk factors for interstitial lung disease (ILD) in rheumatoid arthritis (RA) are inconsistent among previous studies. Furthermore, the factors associated with the emergence of the recently defined progressive fibrosing (PF) phenotype are unknown. Herein, we analyze the risk factors for ILD in RA.
View Article and Find Full Text PDFExtracellular vesicles (EVs) have recently emerged as a source of microbe-specific biomarkers for disease diagnosis. In the present study, we evaluated the utility of pleural fluid-derived extracellular vesicles (pEVs) as a source of Mycobacterium tuberculosis (M. tb.
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