Publications by authors named "S Dhawan"
Objective: Loss of functional β-cell mass is a major cause of diabetes. Thus, identifying regulators of β-cell health is crucial for treating this disease. The Leucine-rich repeat-containing G-protein-coupled receptor (GPCR) 4 (LGR4) is expressed in β-cells and is the fourth most abundant GPCR in human islets.
View Article and Find Full Text PDFIs it possible to monitor fetal movements with a wearable device? A review of novel technologies.
Eur J Obstet Gynecol Reprod Biol
December 2024
Article Synopsis
- Stillbirth is often linked to decreased fetal movements, but current methods for tracking these movements lack accuracy and can lead to unnecessary medical interventions.
- New technologies, including electrocardiography and accelerometry, are being developed to provide more objective and reliable quantification of fetal movements.
- The review highlights the need for improved fetal movement monitoring solutions that allow pregnant women to maintain their daily activities while ensuring their baby's wellbeing is effectively monitored.
Leptomeningeal disease (LMD) is a rare yet serious complication of advanced malignancy, often seen in breast cancer and associated with a poor prognosis. This case report highlights the rapid progression and diagnostic challenges encountered in a woman in her 40s with advanced breast cancer who presented with severe headaches, absence seizures, and diplopia. The patient's complex past history included invasive ductal carcinoma, prior brain metastasis, and recent craniotomy, which added significant challenges to diagnosis and management.
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- The integration of immunohistochemical markers in analyzing small lung biopsy samples enhances the diagnosis of advanced-stage lung carcinoma, particularly for poorly differentiated nonsmall cell lung carcinomas (NSCLCs).
- This study evaluated 130 lung biopsy cases, utilizing a specific set of markers to improve classification accuracy for various types of NSCLC, despite the challenges posed by small sample sizes.
- The combination of TTF1 and p40 markers achieved a high classification success rate (over 94%), showing that a minimal marker panel can effectively subtype NSCLC in resource-limited settings.
Embryonal rhabdomyosarcoma is the malignant mesenchymal proliferation of undifferentiated skeletal muscle. It is the most common soft tissue tumour found in children. Head and neck location accounts for 40% of the cases with the most common variants being of embryonal Nasopharyngeal RMS is a type of parameningeal RMS (arising from tissues adjacent to the meninges) having propensity for CNS and known for having a poorer prognosis, early recurrence, rapid growth and invasion to adjacent structures.
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