Publications by authors named "S Dharmshale"
Article Synopsis
- - The study investigated how sex differences affect tuberculosis (TB) severity, drug exposure, and treatment outcomes, revealing that women generally have a lower mycobacterial burden and face fewer unfavorable treatment outcomes than men.
- - Conducted in India with 1,541 participants, women had a significantly lower risk (35%) of treatment failure or recurrence, with specific factors like cavitary disease increasing risk for women, while men were impacted more by alcohol use and other health metrics.
- - Women demonstrated higher drug exposure levels for isoniazid compared to men, emphasizing the importance of considering sex differences when developing strategies to enhance TB treatment effectiveness.
Article Synopsis
- Diabetes mellitus (DM) increases the risk of tuberculosis (TB), and a study in India compared treatment outcomes between TB patients with and without DM over 18 months.
- Among 799 participants, those with DM had a similar overall rate of unfavorable treatment outcomes (20% for TB-DM vs 21% for TB-only), but had higher mortality rates.
- The study highlighted that early mortality was significantly higher for TB patients with DM, suggesting a need for interventions to improve outcomes for this group.
Pune and Pimpri-Chinchwad Municipal Corporation area, Maharashtra State, India. To assess the sensitivity and specificity of the Xpert MTB/RIF assay among adults with suspected pulmonary tuberculosis (PTB) and with or without diabetes (DM). As part of a prospective cohort study, we screened 2359 adults presumed to have PTB with no history of TB.
View Article and Find Full Text PDFLipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes.
Prostaglandins Other Lipid Mediat
April 2020
Article Synopsis
- * A study involving 40 individuals (20 with newly diagnosed DM and 20 without) analyzed serum samples to quantify pro-inflammatory and pro-resolving lipid mediators, identifying specific lipid families that are abundant in each group.
- * Findings revealed that individuals with TB-DM exhibited stronger connections between pro-inflammatory and pro-resolving lipid mediators than those with TB alone, suggesting a complex molecular balance at play in this comorbidity.
Setting: The optimal timing of screening for diabetes mellitus (DM) among tuberculosis (TB) cases is unclear due to the possibility of stress hyperglycemia.
Design: We evaluated adult (18 years) pulmonary TB cases at treatment initiation as well as at 3 months, 6 months and 12 months. DM was identified by self-report (known DM) or glycated hemoglobin (HbA1c) 6.