Opportunities for predictive proteogenomic biomarkers of drug treatment sensitivity in epithelial ovarian cancer.

Genomic analysis has played a significant role in the identification of driver mutations that are linked to disease progression and response to drug treatment in ovarian cancer. A prominent example is the stratification of epithelial ovarian cancer (EOC) patients with homologous recombination deficiency (HRD) characterized by mutations in DNA damage repair genes such as for treatment with PARP inhibitors. However, recent studies have shown that some epithelial ovarian tumors respond to PARP inhibitors irrespective of their HRD or mutation status.

Aboriginal Community Controlled Organisations Leading the Way in Child Health Research.

Historically, Aboriginal and Torres Strait Islander research in Australia has adhered to Western research paradigms and contributed to the adverse impacts of colonisation. However, recent developments driven by Aboriginal and Torres Strait Islander people and scholars, and development of ethical guidelines for research, have promoted a more inclusive and collaborative research landscape. In this study, published papers and internal documents arising from a long-term partnership between Marninwarntikura Women's Resource Centre (MWRC) and the University of Sydney (USYD) from 2009 to 2023 were analysed using the Aboriginal and Torres Strait Islander Quality Appraisal Tool and consultations with project partners.

Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors.

Background: Poly (ADP-Ribose) polymerase inhibitors are approved for treatment of tumors with BRCA1/2 and other homologous recombination repair (HRR) mutations. However, clinical responses are often not durable and treatment may be detrimental in advanced cancer due to excessive toxicities. Thus we are seeking alternative therapeutics to enhance PARP-directed outcomes.

Predictors of Service Awareness: Results from a Community Survey in an Urban Area.

We examined information seeking strategies and predictors of service awareness from a 2019 survey of Detroit area adults. Participants were age 60+ (mean age = 72.10; SD = 8.