Publications by authors named "S Dev"
Introduction: Current and future astronauts will endure prolonged exposure to spaceflight hazards and environmental stressors that could compromise cognitive functioning, yet cognitive performance in current missions to the International Space Station remains critically under-characterized. We systematically assessed cognitive performance across 10 cognitive domains in astronauts on 6-month missions to the ISS.
Methods: Twenty-five professional astronauts were administered the Cognition Battery as part of National Aeronautics and Space Administration (NASA) Human Research Program Standard Measures Cross-Cutting Project.
Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disorder that affects millions worldwide, presenting challenges in managing symptoms and quality of life. Current treatments include topical corticosteroids (TCS), but novel approaches, such as Janus kinase (JAK) inhibitors, show promise. Baricitinib, a selective JAK1 and JAK2 inhibitor, targets cytokines involved in AD and offers potential benefits beyond traditional therapies.
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- - Peripheral arterial disease (PAD) impacts over 8.5 million Americans and is the top cause of amputations in the U.S., yet there is low awareness among patients and healthcare providers about the condition, highlighting a need for better identification methods.
- - Traditional identification methods, such as keyword search (KWS), are limited by their rigidity and inability to effectively capture undiagnosed PAD cases, making them less effective for varied clinical data.
- - The study explores the use of deep learning (DL) in natural language processing (NLP) to potentially improve the identification of PAD patients through analysis of unstructured clinical notes in electronic health records (EHR), providing a more flexible and accurate approach than KWS.
Article Synopsis
- - T follicular helper cells (Tfh) play a crucial role in B-cell maturation and antibody production in the immune system but have complex effects on tumor immunity, potentially aiding anti-tumor responses or facilitating tumor growth.
- - Their dual role derives from their ability to manipulate cytokine secretion, which influences other immune cells like cytotoxic T cells and natural killer cells.
- - Understanding Tfh cells is essential for optimizing cancer treatments, as they can serve as biomarkers for immunotherapy response and potential targets for new therapeutic strategies in clinical trials.
Background/aim: Low selectivity and high frequency of side-effects are the major problems of currently used chemotherapeutics. Among natural compounds, the polyprenylated acylphloroglucinol, guttiferone E, isolated from Brazilian red propolis, has attracted attention due to its marked anticancer properties and was evaluated here for its role against osimertinib-resistant H1975 cells (with double mutations of epidermal growth factor receptor: EGFR L858R/T790M).
Materials And Methods: Guttiferone E was obtained from red propolis using established extraction procedures.