Publications by authors named "S Della Scala"
The axis CXCL12-CXCR4 is highly expressed in ovarian cancer where contributes to disease progression. Aim of the work was to evaluate the effect of the newly developed CXCR4 antagonist R54 on human ovarian cancer cells aggressiveness. CXCL12-CXCR4 axis was evaluated in human ovarian cancer cells through proliferation, migration and signaling CXCL12-dependents.
View Article and Find Full Text PDFhas been considered for a long time the only causal agent of lactococcosis. In recent years, different papers reported the involvement of other two bacterial species: and . A different host tropism has been described for these species where and are predominant species in fish and humans' infections, while in bovine.
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- Hematopoietic Stem Cell (HSC) gene therapy can potentially provide long-lasting treatment for various genetic blood disorders, but its effects in different patients are not fully understood.
- A study involving 53 patients with conditions like metachromatic leukodystrophy and β-thalassemia showed that the success of HSC gene therapy varies based on disease type, age, and extent of correction.
- The research identified that while half of the treated patients had stem cells with broad lineage potential, the other half showed specific preferences for producing certain types of blood cells based on their underlying conditions, indicating that HSC function adapts to disease circumstances.
Macrocyclization presents a valuable strategy for enhancing the pharmacokinetic and pharmacodynamic profiles of short bioactive peptides. The exploration of various macrocyclic characteristics, such as crosslinking tethers, ring size, and orientation, is generally conducted during the early stages of development. Herein, starting from a potent and selective C-X-C chemokine receptor 4 (CXCR4) cyclic heptapeptide antagonist mimicking the N-terminal region of CXCL12, we demonstrated that the disulfide bridge could be successfully replaced with a side-chain to side-chain lactam bond, which is commonly not enlisted among the conventional disulfide mimetics.
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- * In research using a mouse model that mimics ARO, gene therapy (GT) with lentiviral vectors effectively improved bone density and allowed for long-term survival, while also enhancing the collection of necessary stem cells through a method called plerixafor-induced mobilization.
- * The study suggests that non-genotoxic conditioning before transplantation can lead to better outcomes, including stable stem cell engraftment and improved bone health, providing a