Publications by authors named "S Della Sala"
The central nervous system represents a major target tissue for therapeutic approach of numerous lysosomal storage disorders. Fabry disease arises from the lack or dysfunction of the lysosomal alpha-galactosidase A (GLA) enzyme, resulting in substrate accumulation and multisystemic clinical manifestations. Current enzyme replacement therapies (ERTs) face limited effectiveness due to poor enzyme biodistribution in target tissues and inability to reach the brain.
View Article and Find Full Text PDFThe levels-of-processing framework, proposing that deep encoding enhances retention, plays a crucial role in episodic memory research. Neuroimaging evidence highlights that increased activity of the left ventrolateral prefrontal cortex during deep encoding predicts subsequent memory success. However, cognitive mechanisms underlying this region's involvement in establishing and consolidating deep and shallow traces remain unclear.
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- The study explored how varying spatial working memory (SWM) abilities affect mental rotation (MR) performance, using the Corsi block task (CBT) to categorize participants into higher and lower SWM groups.
- Participants completed a letter rotation task, revealing that those with lower SWM scores made more errors, although reaction times were similar across both groups.
- The findings indicate that lower SWM is associated with longer mental processing times during MR tasks, especially for larger rotation angles, highlighting the significance of SWM in the initial mental representation and execution of MR.
Article Synopsis
- Visuospatial deficits in Huntington's disease (HD) have been studied primarily in terms of visuomotor integration, while visuo-constructive abilities have received less attention, prompting this study to explore those abilities qualitatively in comparison to Alzheimer's disease (AD).
- The study included 41 HD participants, 25 with AD, and 35 healthy controls, who performed tasks like the Constructional Apraxia Test and the Rey-Osterrieth Complex Figure test, revealing no significant quantitative differences in performance between the two patient groups.
- Distinct qualitative error patterns were found, with AD participants showing more simplifications in their drawings and HD participants exhibiting more distortions, highlighting the importance of qualitative analysis in understanding cognitive effects of neurological