Publications by authors named "S Delia"

Arterial hypertension remains the major cardiovascular risk worldwide. It is estimated that under 50 years of age one in every three adults is hypertensive while beyond the age of 50 the prevalence is almost 50% globally. The latest World Health Organization (WHO) Global Report on Hypertension indicated that the global number of hypertensive patients almost doubled in the last three decades, with related increasing deaths, disability, and costs annually.

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Myocarditis is an inflammatory condition of cardiac tissue presenting significant variability in clinical manifestations and outcomes. Its etiology is diverse, encompassing infectious agents (primarily viruses, but also bacteria, protozoa, and helminths) and non-infectious factors (autoimmune responses, toxins, and drugs), though often the specific cause remains unidentified. Recent research has highlighted the potential role of genetic susceptibility in the development of myocarditis (and in some cases the development of inflammatory dilated cardiomyopathy, i.

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Article Synopsis
  • The study focuses on identifying markers that can predict adverse events in patients who had acute myocarditis (AM) to optimize follow-up care.
  • Researchers analyzed data from 248 AM patients, revealing that complicated clinical presentation (CCP) is a strong predictor of major cardiac events compared to other factors like septal late gadolinium enhancement and left ventricular ejection fraction.
  • Findings indicate that while major events post-AM are rare, using CCP, LGE, and LVEF<50% together is effective for identifying those at risk, aiding clinicians in patient monitoring.
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Context: The utility of thyroglobulin (Tg) in the follow-up of differentiated thyroid cancer (DTC) patients has been well-documented. Although third-generation immunoassays have improved accuracy, limitations persist (interfering anti-Tg antibodies and measurement variability). Evolving treatment strategies require a reevaluation of Tg thresholds for optimal patient management.

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Article Synopsis
  • The study investigates 'hot phases' of cardiomyopathy, which involve chest pain and troponin release, and aims to distinguish this condition from acute myocarditis.
  • Researchers analyzed 17 patients who had suspected 'hot-phase cardiomyopathy', assessing them through endomyocardial biopsy (EMB) and genetic tests over a median follow-up of 18 months.
  • The findings revealed that while significant inflammation was rare, apoptosis was common, especially in those with genetic variants linked to cardiomyopathies, suggesting that detecting apoptosis during EMB can inform genetic testing and treatment options.
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