Publications by authors named "S Del Pino"
Magnesium (Mg), the second most abundant intracellular cation, plays a crucial role in cellular functions. In this study, we investigate the interaction between Mg and coenzyme A (CoA), a thiol-containing cofactor central to cellular metabolism also involved in protein modifications. Isothermal titration calorimetry revealed a 1:1 binding stoichiometry between Mg and free CoA under biologically relevant conditions.
View Article and Find Full Text PDF[We must not remain blind to equity: lessons to be learned from the COVID-19 pandemic in the AmericasDeixar de ignorar a equidade: lições a aprender com a pandemia de COVID-19 nas Américas].
Rev Panam Salud Publica
September 2024
Article Synopsis
- The Region of the Americas has long faced social inequalities, particularly in health, due to its colonial history, and the COVID-19 pandemic worsened these disparities among disadvantaged groups.
- This special report analyzes the unequal effects of the pandemic through various lenses, including historical, social, and economic perspectives, highlighting the broader negative impacts of inequality on well-being.
- Strategic recommendations are provided to improve health equity post-pandemic, emphasizing the need for better information systems, more resilient health systems, and targeted policies to address and eliminate health inequities for a more prosperous and sustainable future.
Article Synopsis
- The recreational use of nitrous oxide (NO) has risen recently, leading to more reported cases of toxicity, particularly neurological disorders like subacute combined degeneration (SCD) and polyneuropathy due to vitamin B deficiency.
- Two patients misusing NO exhibited symptoms resembling Guillain-Barré Syndrome (GBS), with MRI findings of transverse myelitis and evidence of mixed polyneuropathy, indicating myeloneuropathy linked to vitamin B deficiency.
- Symptoms improved with vitamin B treatment and stopping NO, highlighting the need for awareness of NO's neurotoxic effects, especially as its use increases.
The structure of the excess proton in liquid water has been the subject of lively debate on both experimental and theoretical fronts for the last century. Fluctuations of the proton are typically interpreted in terms of limiting states referred to as the Eigen and Zundel species. Here, we put these ideas under the microscope, taking advantage of recent advances in unsupervised learning that use local atomic descriptors to characterize environments of acidic water combined with advanced clustering techniques.
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