Publications by authors named "S Del Monte"
Article Synopsis
- Alzheimer's disease (AD) is characterized by various pathological features including amyloid-β deposition and tau hyperphosphorylation, with cerebral microvascular dysfunction likely playing a role in its progression.
- Researchers investigated the microvascular responses and potassium channel activity in an AD mouse model induced by streptozotocin (STZ), using behavioral tests and cellular assays.
- The study found that STZ-AD mice showed poorer performance on behavioral tests and had impaired microvascular responses, which were further deteriorated by exposure to soluble Aβ, indicating a potential link between microvascular dysfunction and AD pathology.
Genetic markers of the Y chromosome are powerful tools for investigating paternal ancestry and are widely used in population and forensic genetics. However, in order to obtain statistics with a higher degree of certainty using these markers, it is necessary to obtain haplotypic frequencies from a representative database, as well as knowing the diversity and structure of the population. The aim of this study was to investigate the genetic diversity of a sample of 1114 unrelated men from three states in the Northeast of Brazil: Paraíba, Pernambuco and Ceará, through the analysis of 23 Y-STRs and to contribute to the expansion of the Brazilian database on these markers.
View Article and Find Full Text PDFExpansion of sodium-glucose cotransporter-2 inhibitor (SGLT2i) use in chronic kidney disease (CKD) prompted a pragmatic study of their safety and effectiveness in patients with type 2 diabetes mellitus (T2DM) and late-stage CKD. The primary clinical endpoint was change in HbA. Secondary clinical endpoints included change in body weight and blood pressure.
View Article and Find Full Text PDFConquering Insulin Network Dysfunctions in Alzheimer's Disease: Where Are We Today?
J Alzheimers Dis
October 2024
Article Synopsis
- Impairments in insulin and IGF signaling in the brain contribute to energy metabolism issues, which are linked to the neurodegeneration seen in Alzheimer's disease, resulting in various brain cell damage and cognitive decline.
- Similar neuropathological processes are observed in other conditions like type 2 diabetes and Parkinson's disease, suggesting common underlying mechanisms.
- Current research is exploring repurposing diabetes medications for Alzheimer's treatment, indicating a need for comprehensive strategies that target multiple signaling pathways to effectively address neurodegeneration.
Dysregulated mTOR networks in experimental sporadic Alzheimer's disease.
Front Cell Neurosci
September 2024
Background: Beyond the signature amyloid-beta plaques and neurofibrillary tangles, Alzheimer's disease (AD) has been shown to exhibit dysregulated metabolic signaling through insulin and insulin-like growth factor (IGF) networks that crosstalk with the mechanistic target of rapamycin (mTOR). Its broad impact on brain structure and function suggests that mTOR is likely an important therapeutic target for AD.
Objective: This study characterizes temporal lobe (TL) mTOR signaling abnormalities in a rat model of sporadic AD neurodegeneration.