Bone marrow transplantation in thalassemia: modifications of hepatic iron overload and associated lesions after long-term engrafting.

Among 450 thalassemic patients treated in the Hematologic Department, 50 patients who were disease-free 4-6 years after allogeneic bone marrow transplantation were sequentially studied by liver biopsy. The patients received marrow from siblings who were genotypically HLA identical at A, B, C and DR loci. For evaluation of siderosis and associated lesions, each patient underwent liver biopsy before, and again 6 months and yearly for 4 to 6 years after bone marrow transplant.

[Human subcutaneous dirofilariasis in Italy. First case in the Marche region].

The first case of human subcutaneous dirofilariasis in the Marche region (Central Italy) is described. It was caused by Dirofilaria repens and localised in the abdominal wall of a 23 years old university student from Pesaro. The presence of many histological sections of the nematode in strong regression, suggests that the death of the parasite occurred inside the nodule many months before the surgical intervention.

Quantitative evaluation of the progressive nuclear abnormalities in urothelial papillary lesions.

The natural history of noninvasive urothelial papillary carcinomas is characterized by structural and nuclear abnormalities of the epithelial lining in the three grades. Morphometry is applied to measure nuclear-related quantitative parameters from the lower (L) and upper (U) halves of urothelial thickness, i.e.