Prokaryotic ancestry and gene fusion of a dual localized peroxiredoxin in malaria parasites.

Horizontal gene transfer has emerged as a crucial driving force for the evolution of eukaryotes. This also includes and related economically and clinically relevant apicomplexan parasites, whose rather small genomes have been shaped not only by natural selection in different host populations but also by horizontal gene transfer following endosymbiosis. However, there is rather little reliable data on horizontal gene transfer between animal hosts or bacteria and apicomplexan parasites.

Comparison of local intravascular drug-delivery catheter systems.

Systemic and local delivery of the photosensitive drug Photofrin polyporphyrin was investigated in normal porcine arteries (n = 192). A macroporous balloon and a novel needle injection catheter were used for local drug delivery and compared with systemic delivery. Fluorescence microscopy combined with digital image analysis was used to quantify the drug-related fluorescence.