Publications by authors named "S Defrere"
Bunge, commonly called danshen, is widely used in traditional Chinese medicine for its cardiovascular and neuroprotective effects, which include antioxidative, anti-inflammatory, and antifibrotic properties. The purpose of this study was to evaluate the preclinical potential of extracts for the treatment of COVID-19. First, the impact of the extract on the binding between SARS-CoV-2 and the cellular ACE2 receptors was assessed using atomic force microscopy (AFM), showing a significant reduction in binding by the extract at concentrations in the µg/mL range.
View Article and Find Full Text PDFObjective: To evaluate, in peritoneal, ovarian, and rectovaginal endometriotic lesions, expression of steroidogenic enzymes involved in the activation and inactivation of estrogens: 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) and 2 (HSD17B2), estrone sulfotransferase (EST), and steroid sulfatase (STS).
Setting: Academic gynecology research unit.
Design: Retrospective study.
Objective: To study the occurrence of nerve fibers in deep nodular endometriotic lesions after nodules were induced in baboons and nerve fiber densities measured 6 months after the grafting procedure.
Design: Experimental animal study.
Setting: Academic gynecology research unit.
Objective: To establish an experimental model for the study of deep nodular endometriosis.
Design: Induction of nodular endometriosis in baboons by grafting different uterine specimens to the peritoneal cavity.
Setting: Research and university facilities.
Objective: To update, analyze, and summarize the literature concerning nuclear factor-kappaB (NF-κB) participation in endometriosis pathophysiology.
Design: Review.
Result(s): Nuclear factor-kappaB is physiologically activated in the human endometrium, showing variable activity.