Publications by authors named "S DeCastro"
General Purpose: To provide a summary of six articles published in 2023 that provide important new data or insights about pressure injuries (PIs).
Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and registered nurses with an interest in skin and wound care.
Learning Objectives/outcomes: After participating in this educational activity, the participant will:1.
Microglia either promote or restrain TRAIL-mediated excitotoxicity caused by Aβ oligomers.
J Neuroinflammation
September 2024
Background: Alzheimer's disease (AD) features progressive neurodegeneration and microglial activation that results in dementia and cognitive decline. The release of soluble amyloid (Aβ) oligomers into the extracellular space is an early feature of AD pathology. This can promote excitotoxicity and microglial activation.
View Article and Find Full Text PDFArticle Synopsis
- Researchers explored the connection between heavy alcohol use and obesity as midlife risk factors for late-onset Alzheimer's disease (LOAD), uncovering a link to disrupted lipophagy and lysosomal function.
- The study found that the loss of lysosomal acid lipase (LAL) in neurons leads to the accumulation of neuronal lysosomal lipids (NLL), which interferes with the clearance of amyloid-beta (Aβ), a key component of Alzheimer's pathology.
- As LAL levels decline with age in both mice and humans, its reduction is associated with increased Aβ and cognitive deficits, highlighting the importance of maintaining LAL function to potentially mitigate Alzheimer's risk as we age.
Objective: The primary purpose of this article is to describe the development and feasibility of the Recovery Narrative Photovoice intervention. The nature of this intervention will be discussed, including facilitating empowerment and a positive sense of identity among people with serious mental illnesses. We will also describe the integration of Photovoice methodology with psychoeducational components, informed by principles of the recovery movement and narrative therapy.
View Article and Find Full Text PDFBackground: Both aortic atherosclerosis (AA) and renal dysfunction are associated with increased morbidity and mortality. We sought to assess the association between AA and renal dysfunction.
Methods: The study consisted of 200 consecutive patients (62% were male, mean age 69 +/- 11 years) who underwent transesophageal echocardiography.