Quality and Safety Considerations for Adaptive Radiation Therapy: An ASTRO White Paper.

Purpose: Adaptive radiation therapy (ART) is the latest topic in a series of white papers published by the American Society for Radiation Oncology addressing quality processes and patient safety. ART widens the therapeutic index by improving the precision of radiation dose to targets, allowing for dose escalation and/or minimization of dose to normal tissue. ART is performed via offline or online methods; offline ART is the process of replanning a patient's treatment plan between fractions, whereas online ART involves plan adjustment with the patient on the treatment table.

Chaperone BiP controls ER stress sensor Ire1 through interactions with its oligomers.

The complex multistep activation cascade of Ire1 involves changes in the Ire1 conformation and oligomeric state. Ire1 activation enhances ER folding capacity, in part by overexpressing the ER Hsp70 molecular chaperone BiP; in turn, BiP provides tight negative control of Ire1 activation. This study demonstrates that BiP regulates Ire1 activation through a direct interaction with Ire1 oligomers.

Atrial Septal Aneurysm Leading to Ischemic Stroke: A Case Report and Literature Review.

Stroke is the most common cause of death and disability in the world, and ischemic etiology plays a major role. Atrial septal aneurysm (ASA) is a localized saccular deformity of the atrial septum, associated with ischemic stroke independently or in association with other atrial septal defects (ASD). There is a higher incidence of stroke in the population with ASD.

Synthesis of gold-tin alloy nanoparticles with tunable plasmonic properties.

Plasmonic nanoparticles and nanocrystalline materials have broad applicability in catalysis, optoelectronics, sensing, and sustainability. Below, we detail a robust protocol for the synthesis of bimetallic Au-Sn nanoparticles in mild, aqueous conditions. This protocol describes the steps for synthesizing gold nanoparticle seeds, diffusing Sn into the seeds by chemical reduction, and the optical and structural analysis by UV-visible spectroscopy, X-ray diffraction, and electron microscopy.