Caspase-2 protects against ferroptotic cell death.

Caspase-2, one of the most evolutionarily conserved members of the caspase family, is an important regulator of the cellular response to oxidative stress. Given that ferroptosis is suppressed by antioxidant defense pathways, such as that involving selenoenzyme glutathione peroxidase 4 (GPX4), we hypothesized that caspase-2 may play a role in regulating ferroptosis. This study provides the first demonstration of an important and unprecedented function of caspase-2 in protecting cancer cells from undergoing ferroptotic cell death.

Morphological and Molecular note on the identity of Cobb, 1917 (Nematoda: Mylonchulidae) from Pakistan.

A species of predatory nematode, Cobb, 1917, was recovered around the soil and roots of banana plants () from four different localities of Pakistan. The male of this species represents a new record from Pakistan. Morphological and morphometric data of the species have been contributed along with the molecular study.

Exploring social stages of play through eye to I© intervention model.

The study explores the role of the Eye to I© intervention model in facilitating advancement through social stages of play in which skills contribute to the quality of social interaction and communication in children with autism. Data were collected on 11 participants, ages of 2-6 years, formally diagnosed with autism, receiving Eye to I© Social Communication therapy at Potentials Therapy Center, New Delhi, India. Eye to I© is developed in-house at Potentials and is further discussed in the paper.

Segmentation of OECD countries on the basis of selected global environmental indicators using k-means non-hierarchical clustering.

In order to allocate resources and describe progress, frequently nations are grouped together by many international authorities. A variety of pertinent indicators can provide a more useful basis for classification for each specific area of interest. Based on commonalities between various variables connected to the global environmental sector, we developed a novel typology of country clusters.