DEK::AFF2 Fusion Sinonasal and Skull Base Nonkeratinizing Squamous Cell Carcinoma: A Clinical Outcome Study Compared With Conventional Sinonasal Squamous Cell Carcinoma.

DEK::AFF2 fusion nonkeratinizing squamous cell carcinoma (NKSCC) is an emerging entity in the sinonasal tract, temporal bone, and skull base. However, the clinical behavior of these tumors has not been well studied. Here, we report the largest cohort of DEK::AFF2 carcinomas to determine if morphology, mitotic rate, and/or Ki-67 IHC are associated with patient outcomes, including a comparison with high-risk human papillomavirus (HPV)-associated and independent patients.

Evaluating the impact of a tertiary multidisciplinary meeting in metastatic breast cancer: A prospective study.

Background: Metastatic breast cancer (mBC) guidelines recommend multidisciplinary meetings (MDM), but there is limited research on their impact. This prospective study examines the impact of an mBC MDM on management plans, their implementation rate, and costs and benefits at an Australian metropolitan breast cancer center.

Methods: Consecutive mBC MDM patients were enrolled.

Reassignment of a junior synonym of Lepisosteus oculatus Winchell 1864 to L. platostomus Rafinesque 1820.

N/A.

Convolutional neural network models describe the encoding subspace of local circuits in auditory cortex.

Auditory cortex encodes information about nonlinear combinations of spectro-temporal sound features. Convolutional neural networks (CNNs) provide an architecture for generalizable encoding models that can predict time-varying neural activity evoked by natural sounds with substantially greater accuracy than established models. However, the complexity of CNNs makes it difficult to discern the computational properties that support their improved performance.