Publications by authors named "S Darne"
Background: In children, psoriasis can be challenging to diagnose. Difficulties arise from differences in the clinical presentation compared with adults.
Objectives: To test the diagnostic accuracy of previously agreed consensus criteria and to develop a shortlist of the best predictive diagnostic criteria for childhood psoriasis.
Background: Recessive forms of congenital ichthyosis encompass a group of rare inherited disorders of keratinization leading to dry, scaly skin. So far, 13 genes have been implicated, but there is a paucity of data on genotype-phenotype correlation in some populations.
Objectives: We compiled an English cohort of 146 individuals with recessive ichthyosis and assessed genotype-phenotype correlation.
Article Synopsis
- The study was a randomized, double-blind trial aimed at comparing the pharmacokinetics, safety, and immunogenicity of the adalimumab biosimilar M923 with two reference products, US Humira and EU Humira, using a single 40-mg dose.
- Results showed that M923 demonstrated pharmacokinetic equivalence to both reference products, with geometric least squares means ratios for key endpoints (C_max, AUC_inf, AUC_336) falling within the acceptable range of 80%-125%.
- Adverse events were similar across all groups, mostly mild or moderate, and confirmed antidrug antibody response rates were also comparable, indicating that M923 is safe and tolerable like its