Publications by authors named "S Darbha"
β-arrestins are multifunctional intracellular proteins that regulate the desensitization, internalization and signaling of over 800 different G protein-coupled receptors (GPCRs) and interact with a diverse array of cellular partners. Beyond the plasma membrane, GPCRs can initiate unique signaling cascades from various subcellular locations, a phenomenon known as "location bias". Here, we investigate how β-arrestins direct location-biased signaling of the angiotensin II type I receptor (AT1R).
View Article and Find Full Text PDFPurpose: This study aimed to describe healthcare resource utilization and costs among individuals with vitiligo who were diagnosed with ≥1 psychosocial comorbidity, using data from US claims databases.
Patients And Methods: A retrospective, observational cohort analysis of the IBM MarketScan Commercial and Medicare supplemental claims databases for US individuals with vitiligo aged ≥12 years and a first vitiligo claim between January 1 and December 31, 2018, was undertaken to assess psychosocial burden, including mental and behavioral health comorbidities.
Results: Of the 12,427 individuals included in the analysis, nearly 1 in 4 (23.
Article Synopsis
- Germinal centers (GCs) in mucosal sites are influenced by gut-derived factors, which can affect B cell homeostasis without depending solely on antigen receptor signals.
- The G-protein Gα13 plays a key role in keeping B cells confined to the GC, and its deficiency can lead to increased GC activity and potentially lymphoma development due to enhanced mTORC1 signaling and Myc protein expression.
- Gα13-deficient B cells in the mesenteric lymph node gain a competitive edge by relying on dietary nutrients like glutamine for growth and proliferation, highlighting how alterations in pathways can impact the development of aggressive lymphomas in the gut.
Phenyl boronic acids are valuable for medical diagnostics and biochemistry studies due to their ability to readily bind with carbohydrates in water. Incorporated in carbohydrates are 1,2-diols, which react with boronic acids through a reversible covalent condensation pathway. A wide variety of boronic acids have been employed for diol binding with differing substitution of the phenyl ring, with the goals of simplifying their synthesis and altering their thermodynamics of complexation.
View Article and Find Full Text PDFFacial Nerve Palsy as a Common Presentation during the Epidemic of Coronavirus Disease Associated Rhinocerebral Mucormycosis.
Indian J Otolaryngol Head Neck Surg
October 2022
Purpose: The main purpose of this study is to highlight the involvement of the facial nerve as one of the presenting symptoms in patients suspected of coronavirus disease associated mucormycosis (CAM).
Methods: This is a retrospective observational study conducted at a tertiary care referral centre which included 300 patients with past history of being treated for coronavirus disease and who presented to our department with symptoms of invasive fungal sinusitis. All the patients were evaluated clinically and radiologically for presence of facial nerve palsy (FNP) in suspected cases of CAM.